Vitamin D Analogs & D2
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Over 70 years Vitamin D experience in The Netherlands

CARBOGEN AMCIS B.V. is active in the manufacturing, marketing/sales and distribution of Vitamin D analogs and Vitamin D2 (Ergocalciferol). These ingredients (APIs) are mainly used in pharmaceutical products. Through our history of Philips, Roxane, Duphar, and Solvay Pharmaceuticals, we have more than 70 years of experience in the development, production, and sales of these ingredients (APIs). Our production site in the Netherlands is operated under cGMP regime, is certified as EU GMP, and classified as acceptable by US FDA for API manufacturing. We have our own testing laboratory.

We control the complete supply chain by manufacturing our own raw material for these Vitamin D ingredients. From the Netherlands we ship these products worldwide. We can also be your partner for HIPO contract manufacturing and/or contract research (CRAMS) of Vitamin D related intermediates and APIs.

  • Alfacalcidol PhEur / IP / BP

    Application:
    Alfacalcidol is a Vitamin D3 analog for the Pharmaceutical and Veterinary industry. Alfacalcidol is especially used to prevent and treat osteoporosis or decalcification of bones. The substance is also active against other bone growth disorders such as osteomalacia, rickets and specific liver and parathyroid glands abnormalities. It is also used for the treatment and prevention of secondary hyperparathyroidism associated with chronic kidney disease (CKD).

    Specification:
    Names: Alfacalcidol; 1α-hydroxycholecalciferol; 1α-hydroxyvitamin D3
    Content Alfacalcidol (HPLC) is 97.0-102.0%

    CAS: 41294-56-8

    Regulatory: CEP/CoS and DMF available

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  • Calcitriol PhEur / USP / IP / BP

    Application:
    Calcitriol is a Vitamin D3 analog for the Pharmaceutical and Veterinary industry. Calcitriol is especially used to prevent and treat osteoporosis or decalcification of bones. The substance is also active against other bone growth disorders such as osteomalacia, rickets and specific liver and parathyroid glands abnormalities. It is also used for the treatment and prevention of secondary hyperparathyroidism associated with chronic kidney disease (CKD).

    Specification:
    Names: Calcitriol; 1α,25-dihydroxycholecalciferol; 1α,25-dihydroxyvitamin D3; 1,25 DHCC
    Content Calcitriol (HPLC) is 97.0-102.0%

    CAS: 32222-06-3

    Regulatory: CEP/CoS and DMF available

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  • Calcifediol PhEur / USP / IP / BP

    Application:
    Calcifediol is a Vitamin D3 analog for the Pharmaceutical and Veterinary industry. Calcifediol is especially used to prevent and treat osteoporosis or decalcification of bones. The substance is also active against other bone growth disorders such as rickets, osteomalacia and specific liver and parathyroid glands abnormalities. It is also used for the treatment and prevention of secondary hyperparathyroidism associated with chronic kidney disease (CKD).

    Specification:
    Names: Calcifediol; 25-hydroxyvitamin D3;25-hydroxycholecalciferol; 25-HCC
    Content Calcifediol (HPLC) is 97.0-102.0%

    CAS: 63283-36-3 (monohydrate), 19356-17-3 (anhydrous)

    Regulatory: CEP/CoS and DMF available

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  • Dihydrotachysterol-2 PhEur / USP / BP

    Application:
    Dihydrotachysterol-2 (DHT-2) is a Vitamin D2 analog for the Pharmaceutical industry. DHT2 is used in the prevention and treatment of several bone growth disorders such as osteoporosis. Besides this the substance is also used to treat several abnormalities of the parathyroid glands such as hypoprathyroidism.

    Specification:
    Names: Dihydrotachysterol-2; DHT-2; DHT
    Content Dihydrotachysterol-2 (HPLC) is 97.0-102.0%

    CAS: 67-96-9

    Regulatory: CEP/CoS and DMF available

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  • Doxercalciferol

    Application:
    Doxercalciferol is an active Vitamin D2 analog for the Pharmaceutical industry. Doxercalciferol is used for the treatment and prevention of secondary hyperparathyroidism associated with chronic kidney disease (CKD). It has been shown to reduce parathyroid hormone levels by inhibiting its synthesis and secretion.

    Specification:
    Names: Doxercalciferol; 1α-hydroxyergocalciferol; 1α-hydroxy D2; Ercalcidol
    Content Doxercalciferol (HPLC) is 97.0-102.0%

    CAS: 54573-75-0

    Regulatory: R&D phase

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  • Ergocalciferol PhEur / USP / BP - Vitamin D2 pure

    Application:
    Vitamin D2 is used to ensure the right concentration of calcium and phosphorus in the blood. Ergocalciferol is used to treat and prevent bone growth disorders such as osteomalacia, rickets and osteoporosis. Recent research shows that Vitamin D2 can also be of paramount importance to prevent other abnormalities and diseases as well. Several forms of cancer and auto-immune diseases are targeted by several research companies. Vitamin D2 can also be used as starting material for APIs.

    Specification:
    Names: Vitamin D2 pure; Ergocalciferol; Calciferol
    Content Ergocalciferol is 97.0-102.0%; 1 gram is equivalent to 40,000,000 IU of Vitamin D2

    CAS: 50-14-6

    Regulatory: DMF available (an ASMF has been filed and accepted in several European countries)

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  • Paricalcitol USP

    Application:
    Paricalcitol is an active Vitamin D2 analog for the Pharmaceutical industry. Paricalcitol is used for the treatment and prevention of secondary hyperparathyroidism associated with chronic kidney disease (CKD). It has been shown to reduce parathyroid hormone levels by inhibiting its synthesis and secretion.

    Specification:
    Names: Paricalcitol; 19-NOR-1α,25-dihydroxyergocalciferol; 19-NOR-1α,25-dihydroxy D2
    Content Paricalcitol (HPLC) is 97.0-103.0%

    CAS: 131918-61-1

    Regulatory: DMF available (an ASMF has been filed and accepted in several European countries)

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  • Secalciferol

    Application:
    Secalciferol is an active Vitamin D analog for the Pharmaceutical industry. Secalciferol can be used for the treatment of disorders in Calcium and Phosphor homeostasis. It can also be used as a marker for Vitamin D3 catabolism and a predictor of serum 25-hydroxycholecalciferol response to Vitamin D3 supplementation.

    Specification:
    Names: Secalciferol; 24R,25-dihydroxycholecalciferol; 24R,25-dihydroxyvitamin D3; 24R 25 DHCC
    Content Secalciferol (HPLC) is ≥ 95%

    CAS: 55721-11-4

    Regulatory: Non-GMP material

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More than

70

years

of experience

Production from mg to several

100

metric

tons

Products distributed across

65

+

countries

For more information
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brochure or contact us today.