Discovery & Development of a New ADC
CARBOGEN AMCIS & Heidelberg Pharma Formula for Successful Collaboration
During the BOS Basel, on the 08 June 2022, Heidelberg Pharma (Dr. Christan Lutz) and CARBOGEN AMCIS (Dr. Thomas Schlatterer) held a presentation about their collaboration and the ADC development. The cyclic peptide α-Amanitin and analogue amatoxins have been investigated for over sixty years mostly by extraction from death cap mushrooms of the species Amanita phalloides. α-Amanitin is a highly selective and potent inhibitor of eukaryotic RNA polymerase II. Despite such exceptional biological activity and pharmacological potential, the total synthesis of α-Amanitin and related compounds still remain a very challenging task, due to unique structural features.
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About the speakers
Dr. Thomas Schlatterer
CARBOGEN AMCIS, Head of Sales Europe & Asia Pacific
Thomas Schlatterer received a Ph.D. in organic chemistry (heterocyclic chemistry) at the University of Konstanz, Germany. He joined CARBOGEN AMCIS in 2001 at the Aarau site as a project chemist leading several production projects. In 2003 he moved to the Hunzenschwil site to work in his new position as Manager of Project Coordination and 2 years later joined the sales team responsible for Germany, Switzerland and Austria. Thomas has expertise in contract chemical process, R&D, and analytical chemistry in the field of active pharmaceutical ingredients (APIs) including highly potent molecules. In his current position is heading the sales team in Europe & Asia Pacific.
Dr. Christian Lutz
Heidelberg Pharma Research GmbH, Director Project Management CMC
Dr. Christian Lutz is working at Heidelberg Pharma Research as a director of project management CMC. He has more than 20 years’ experience in the biotechnology industry. His previous roles included synthetic organic chemistry, analytics, and bio-analytics. Christian currently oversees the ADC development and production at Heidelberg Pharma Research. He obtained his PhD in organic chemistry from the University of Marburg, Germany
Find the whole presentation as PDF here:
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