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1,8-diazabicyclo[6.6.6]eicosa-4,11,17-triyne and 1,8-diazacyclotetradeca-4,11-diyne.

The syntheses of 1,8-diazacyclotetradeca-4,11-diyne and 1,8-diazabicyclo[6.6.6]eicosa-4,11,17-triyne and 1,8-diazabicyclo[6.6.6]eicosa-4,11,17-triene are reported.
Published: 07.09.18

1,8-Diazabicyclo[6.6.4]octadeca-4,11,16-triyne - A bridgehead amine with planar nitrogens

The synthesis of 1,8-diazabicyclo[6.6.4]octadeca-4,11,16-triyne (3) has been achieved, X-ray investigations on single crystals reveal an almost planar conformation of the nitrogen atoms.
Published: 07.09.18

Synthesis and Structural Properties of Bridged 1,8‐Diazacyclotetradeca‐4,11‐diynes

The synthesis of 1,8‐diazacyclotetradeca‐4,11‐diyne (4) was accomplished by reaction of 1,6‐dibromo‐3‐hexyne (11) with ammonia.
Published: 07.09.18

Reactions of 1,8‐Diheterocyclotetradeca‐4,11‐diynes with (η4‐Cycloocta‐1,5‐diene)(η5‐cyclopentadienyl)cobalt

The following monocyclic and bicyclic 14‐membered diynes were treated with [CpCo(cod)]: 1‐oxacyclotetradeca‐4,11‐diyne
Published: 07.09.18

A short survey of bicyclic diamines – syntheses and properties of N,N′-bridged-1,10-diazabicyclooctadeca-5,14-diynes

The conformations and properties of 1,(k + 2)-diazabicyclo[k.l.m]alkanes are reviewed briefly.
Published: 07.09.18

Reaction of N,N'-bridged 1,10-diazacyclooctadeca-5,14-diynes with [CpCo(cod)]: a new type of superphane

The reaction of N,N′-bridged 1,10-diazacyclooctadeca-5,14-diynes 1a–d with [CpCo(cod)] (2) leads to both intra- (3) and inter-molecular (4) CpCo–cyclobutadiene complexes.
Published: 07.09.18

A Short and Efficient Synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2- carboxylic Acid

A short and efficient synthesis of (S)-1-(tert-butoxycarbonyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid is described
Published: 07.09.18

Example of a Stereoselective Synthesis in Industrial API Manufacture

Stereoselective transformation performed on multi-kilogram scale at CARBOGEN AMCIS
Published: 29.08.18

Process Development and Multikilogram Syntheses of XL228

Org. Process Res. Dev., 2013, 17 (8), pp 1066–1073
Published: 06.09.13

Safety Assessment for the Scale-up of an Oxime Reduction with Melted Sodium in Standard Pilot-Plant Equipment

Org. Process Res. Dev., Article ASAP, 2012, DOI: 10.1021/op300101d
Published: 02.06.12

Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182)

Angewandte Chemie International Edition, 49: 5693–5697. doi: 10.1002/anie.201001026
Published: 13.07.10

Implementation of a High-Temperature Claisen Approach for Early Phase Delivery of a Benzopyran Derivative

Organic Process Research & Development 2010, 14, 85–91
Published: 18.04.10

Development of a Scalable Synthetic Route to GSK369796 (N-tert-Butyl Isoquine), a Novel 4-Aminoquinoline Antimalarial Drug

Organic Process Research & Development 2008, 12, 294–297
Published: 18.04.08

Preparation of a HMG-CoA Reductase Inhibitor via an Optimized Imidazole-Forming Condensation Reaction

Organic Process Research & Development 2008, 12, 1183–1187
Published: 18.04.08

2-(Diethylamino)ethanethiol, a New Reagent for the Odorless Deprotection of Aromatic Methyl Ethers

J. Org. Chem., 2006, 71 (18), pp 7103–7105
Published: 18.04.06

First Safe and Practical Synthesis of 2-Amino-8-hydroxyquinoline

Organic Process Research & Development 2004, 8, 663-665
Published: 18.04.04

Chiroptical Properties of Some Monoazapentahelicenes

J. Phys. Chem. A, 2004, 108 (52), pp 11752–11761
Published: 18.04.04

Development of a Scaleable Route for the Production of cis-N-Benzyl-3-methylamino-4-methylpiperidine

Org. Process Res. Dev., 2003, 7 (1), pp 115–120
Published: 18.04.03

Large-Scale Preparation of 3-Methyl-4H-[1,2,4]oxadiazol-5-one, Potassium or Sodium Salt

Organic Process Research & Development 2002, 6, 896-897
Published: 18.04.02