Synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2- carboxylic Acid

A short and efficient synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carboxylic acid is described.

Tuesday, 31 March 2020

A short and efficient synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carboxylic acid is described. Starting from N-Boc-diallylamine, the synthesis involves ring-closing metathesis (RCM), directed alkoxycarbonylation (using strong lithium bases and alkyl carbonates) and enzymatic kinetic resolution of the racemate.

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