Knowledge Centre

Welcome to the CARBOGEN AMCIS Knowledge Centre

We want to share our knowledge with the Life Sciences industry in the hope that this information may help you overcome the challenges you face across all stages of the drug development process.

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Press Mentions

1,8-diazabicyclo[6.6.6]eicosa-4,11,17-triyne and 1,8-diazacyclotetradeca-4,11-diyne.

The syntheses of 1,8-diazacyclotetradeca-4,11-diyne and 1,8-diazabicyclo[6.6.6]eicosa-4,11,17-triyne and 1,8-diazabicyclo[6.6.6]eicosa-4,11,17-triene are reported.
Published: 07.09.18

1,8-Diazabicyclo[6.6.4]octadeca-4,11,16-triyne - A bridgehead amine with planar nitrogens

The synthesis of 1,8-diazabicyclo[6.6.4]octadeca-4,11,16-triyne (3) has been achieved, X-ray investigations on single crystals reveal an almost planar conformation of the nitrogen atoms.
Published: 07.09.18

Synthesis and Structural Properties of Bridged 1,8‐Diazacyclotetradeca‐4,11‐diynes

The synthesis of 1,8‐diazacyclotetradeca‐4,11‐diyne (4) was accomplished by reaction of 1,6‐dibromo‐3‐hexyne (11) with ammonia.
Published: 07.09.18

Reactions of 1,8‐Diheterocyclotetradeca‐4,11‐diynes with (η4‐Cycloocta‐1,5‐diene)(η5‐cyclopentadienyl)cobalt

The following monocyclic and bicyclic 14‐membered diynes were treated with [CpCo(cod)]: 1‐oxacyclotetradeca‐4,11‐diyne
Published: 07.09.18

A short survey of bicyclic diamines – syntheses and properties of N,N′-bridged-1,10-diazabicyclooctadeca-5,14-diynes

The conformations and properties of 1,(k + 2)-diazabicyclo[k.l.m]alkanes are reviewed briefly.
Published: 07.09.18

Reaction of N,N'-bridged 1,10-diazacyclooctadeca-5,14-diynes with [CpCo(cod)]: a new type of superphane

The reaction of N,N′-bridged 1,10-diazacyclooctadeca-5,14-diynes 1a–d with [CpCo(cod)] (2) leads to both intra- (3) and inter-molecular (4) CpCo–cyclobutadiene complexes.
Published: 07.09.18

A Short and Efficient Synthesis of (S)-1-Boc-2,5-dihydro-1H-pyrrole-2- carboxylic Acid

A short and efficient synthesis of (S)-1-(tert-butoxycarbonyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid is described
Published: 07.09.18

Example of a Stereoselective Synthesis in Industrial API Manufacture

Stereoselective transformation performed on multi-kilogram scale at CARBOGEN AMCIS
Published: 29.08.18

Process Development and Multikilogram Syntheses of XL228

Org. Process Res. Dev., 2013, 17 (8), pp 1066–1073
Published: 06.09.13

Safety Assessment for the Scale-up of an Oxime Reduction with Melted Sodium in Standard Pilot-Plant Equipment

Org. Process Res. Dev., Article ASAP, 2012, DOI: 10.1021/op300101d
Published: 02.06.12

Identification of a 1,2,4,5-Tetraoxane Antimalarial Drug-Development Candidate (RKA 182)

Angewandte Chemie International Edition, 49: 5693–5697. doi: 10.1002/anie.201001026
Published: 13.07.10

Implementation of a High-Temperature Claisen Approach for Early Phase Delivery of a Benzopyran Derivative

Organic Process Research & Development 2010, 14, 85–91
Published: 18.04.10

Development of a Scalable Synthetic Route to GSK369796 (N-tert-Butyl Isoquine), a Novel 4-Aminoquinoline Antimalarial Drug

Organic Process Research & Development 2008, 12, 294–297
Published: 18.04.08

Preparation of a HMG-CoA Reductase Inhibitor via an Optimized Imidazole-Forming Condensation Reaction

Organic Process Research & Development 2008, 12, 1183–1187
Published: 18.04.08

2-(Diethylamino)ethanethiol, a New Reagent for the Odorless Deprotection of Aromatic Methyl Ethers

J. Org. Chem., 2006, 71 (18), pp 7103–7105
Published: 18.04.06

First Safe and Practical Synthesis of 2-Amino-8-hydroxyquinoline

Organic Process Research & Development 2004, 8, 663-665
Published: 18.04.04

Chiroptical Properties of Some Monoazapentahelicenes

J. Phys. Chem. A, 2004, 108 (52), pp 11752–11761
Published: 18.04.04

Development of a Scaleable Route for the Production of cis-N-Benzyl-3-methylamino-4-methylpiperidine

Org. Process Res. Dev., 2003, 7 (1), pp 115–120
Published: 18.04.03

Large-Scale Preparation of 3-Methyl-4H-[1,2,4]oxadiazol-5-one, Potassium or Sodium Salt

Organic Process Research & Development 2002, 6, 896-897
Published: 18.04.02

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